34 publications

2019

• Ding, Y., Murphy, K. M., Poretsky, E., Mafu, S., Yang, B., Char, S. N., ... Schmelz, E. A. (2019). Multiple genes recruited from hormone pathways partition maize diterpenoid defences. Nature Plants, 5(10), 1043-1056. doi: 10.1038/s41477-019-0509-6
• Seiler, G. S., & Hughes, C. C. (2019). Progress toward the total synthesis of lymphostins: Preparation of a functionalized tetrahydropyrrolo 4,3,2-de quinoline and unusual oxidative dimerization. Journal of Organic Chemistry, 84(14), 9339-9343. doi: 10.1021/acs.joc.9b01041
• Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature's combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027-9031. doi: 10.1002/anie.201902571

2018

• Kearney, S. E., Zahoranszky-Kohalmi, G., Brimacombe, K. R., Henderson, M. J., Lynch, C., Zhao, T. G., ... Rohde, J. M. (2018). Canvass: A crowd-sourced, natural-product screening library for exploring biological space. Acs Central Science, 4(12), 1727-1741. doi: 10.1021/acscentsci.8b00747
• Castro-Falcon, G., Seiler, G. S., Demir, O., Rathinaswamy, M. K., Hamelin, D., Hoffmann, R. M., ... Hughes, C. C. (2018). Neolymphostin A Is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester. Journal of Medicinal Chemistry, 61(23), 10463-10472. doi: 10.1021/acs.jmedchem.8b00975
• Castro-Falcon, G., Millan-Aguinaga, N., Roullier, C., Jensen, P. R., & Hughes, C. C. (2018). Nitrosopyridine probe to detect polyketide natural products with conjugated alkenes: Discovery of novodaryamide and nocarditriene. Acs Chemical Biology, 13(11), 3097-3106. doi: 10.1021/acschembio.8b00598
• Patin, N. V., Floros, D. J., Hughes, C. C., Dorrestein, P. C., & Jensen, P. R. (2018). The role of inter-species interactions in Salinispora specialized metabolism. Microbiology-Sgm, 164(7), 946-955. doi: 10.1099/mic.0.000679
• Mafu, S., Ding, Y. Z., Murphy, K. M., Yaacoobi, O., Addison, J. B., Wang, Q., ... Zerbe, P. (2018). Discovery, biosynthesis and stress-related accumulation of dolabradiene-derived defenses in maize. Plant Physiology, 176(4), 2677-2690. doi: 10.1104/pp.17.01351

2017

• Gallagher, K. A., Wanger, G., Henderson, J., Llorente, M., Hughes, C. C., & Jensen, P. R. (2017). Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environmental Microbiology, 19(6), 2182-2191. doi: 10.1111/1462-2920.13700
• Reimer, D., & Hughes, C. C. (2017). Thiol-based probe for electrophilic natural products reveals that most of the ammosamides are artifacts. Journal of Natural Products, 80(1), 126-133. doi: 10.1021/acs.jnadprod.6b00773

2016

• Castro-Falcon, G., Hahn, D., Reimer, D., & Hughes, C. C. (2016). Thiol probes to detect electrophilic natural products based on their mechanism of action. Acs Chemical Biology, 11(8), 2328-2336. doi: 10.1021/acschembio.5b00924

2015

• Richter, T. K. S., Hughes, C. C., & Moore, B. S. (2015). Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environmental Microbiology, 17(6), 2158-2171. doi: 10.1111/1462-2920.12669

2013

• Alvarez-Mico, X., Jensen, P. R., Fenical, W., & Hughes, C. C. (2013). Chlorizidine, a Cytotoxic 5H-Pyrrolo 2,1-a isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp. Organic Letters, 15(5), 988-991. doi: 10.1021/ol303374e
• Yang, M. H., Liu, Z., Hughes, C., Stern, A. M., Wang, H., Zhong, Z. T., ... Zhu, J. (2013). Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence. Proceedings of the National Academy of Sciences of the United States of America, 110(6), 2348-2353. doi: 10.1073/pnas.1218039110

2012

• Yamanaka, K., Ryan, K. S., Gulder, T. A. M., Hughes, C. C., & Moore, B. S. (2012). Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis. Journal of the American Chemical Society, 134(30), 12434-12437. doi: 10.1021/ja305670f

2011

• Haste, N. M., Hughes, C. C., Tran, D. N., Fenical, W., Jensen, P. R., Nizet, V., & Hensler, M. E. (2011). Pharmacological properties of the marine natural product marinopyrrole a against methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 55(7), 3305-3312. doi: 10.1128/aac.01211-10

2010

• Hughes, C. C., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2010). Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. Journal of Organic Chemistry, 75(10), 3240-3250. doi: 10.1021/jo1002054
• Hughes, C. C., & Fenical, W. (2010). Total synthesis of the ammosamides. Journal of the American Chemical Society, 132(8), 2528-2529. doi: 10.1021/ja9106572
• Hughes, C. C., & Fenical, W. (2010). Antibacterials from the sea. Chemistry-a European Journal, 16(42), 12512-12525. doi: 10.1002/chem.201001279
• Pangerl, M., Hughes, C. C., & Trauner, D. (2010). Total Synthesis of Newbouldine via Reductive N–N Bond Formation. Tetrahedron, 66(33), 6626-6631.

2009

• Nett, M., Guider, T. A. M., Kale, A. J., Hughes, C. C., & Moore, B. S. (2009). Function-Oriented Biosynthesis of beta-Lactone Proteasome Inhibitors in Salinispora tropica. Journal of Medicinal Chemistry, 52(19), 6163-6167. doi: 10.1021/Jm901098m
• Hughes, C. C., Yang, Y. L., Liu, W. T., Dorrestein, P. C., La Clair, J. J., & Fenical, W. (2009). Marinopyrrole A target elucidation by acyl dye transfer. Journal of the American Chemical Society, 131(34), 12094-+. doi: 10.1021/ja903149u
• Hughes, C. C., MacMillan, J. B., Gaudencio, S. R., Jensen, P. R., & Fenical, W. (2009). The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angewandte Chemie-International Edition, 48(4), 725-727. doi: 10.1002/anie.200804890
• Hughes, C. C., MacMillan, J. B., Gaudencio, S. P., Fenical, W., & La Clair, J. J. (2009). Ammosamides A and B target myosin. Angewandte Chemie-International Edition, 48(4), 728-732. doi: 10.1002/anie.200804107

2008

• Hughes, C. C., Prieto-Davo, A., Jensen, P. R., & Fenical, W. (2008). The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.. Organic Letters, 10(4), 629-631. doi: 10.1021/ol702952n

2006

• Miller, A. K., Hughes, C. C., Kennedy-Smith, J. J., Gradl, S. N., & Trauner, D. (2006). Total Synthesis of (−)-Heptemerone B and (−)-Guanacastepene E. Journal of the American Chemical Society, 128(51), 17057-17062.

2005

• Bowie, A. L., Hughes, C. C., & Trauner, D. (2005). Concise Synthesis of (±)-Rhazinilam through Direct Coupling. Organic Letters, 7(23), 5207-5209.
• Endicott, C. A., Strauss, H. L., Hughes, C. C., & Trauner, D. (2005). Infrared Hole Burning and Conformational Change in a Borane−Ammonia Complex. The Journal of Physical Chemistry A, 109(34), 7714-7717. doi: 10.1021/jp051969i
• Hughes, C. C., Miller, A. K., & Trauner, D. (2005). An Electrochemical Approach to the Guanacastepenes. Organic Letters, 7(16), 3425-3428. doi: 10.1021/ol047387l

2004

• Hughes, C. C., & Trauner, D. (2004). Palladium-Catalyzed Couplings to Nucleophilic Heteroarenes: the Total Synthesis of (−)-Frondosin B. Tetrahedron, 60(43), 9675-9686.

2003

• Hughes, C. C., Kennedy-Smith, J. J., & Trauner, D. (2003). Synthetic Studies toward the Guanacastepenes. Organic Letters, 5(22), 4113-4115. doi: 10.1021/ol035559t

2002

• Hughes, C. C., Scharn, D., Mulzer, J., & Trauner, D. (2002). Borane−Ammonia Complexes Stabilized by Hydrogen Bonding. Organic Letters, 4(23), 4109-4111. doi: 10.1021/ol026865u
• Hughes, C. C., & Trauner, D. (2002). The Total Synthesis of (−)-Amathaspiramide F. Angewandte Chemie, 114(23), 4738-4741. doi: 10.1002/1521-3757(20021202)114:23<4738::AID-ANGE4738>3.0.CO;2-C
• Hughes, C. C., & Trauner, D. (2002). Concise Total Synthesis of (−)-Frondosin B Using a Novel Palladium-Catalyzed Cyclization. Angewandte Chemie International Edition, 41(9), 1569-1572. doi: 10.1002/1521-3773(20020503)41:9<1569::AID-ANIE1569>3.0.CO;2-8